McKinley
发表于 2025-3-21 18:39:23
书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases影响因子(影响力)<br> http://figure.impactfactor.cn/if/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases影响因子(影响力)学科排名<br> http://figure.impactfactor.cn/ifr/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases网络公开度<br> http://figure.impactfactor.cn/at/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases网络公开度学科排名<br> http://figure.impactfactor.cn/atr/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases被引频次<br> http://figure.impactfactor.cn/tc/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases被引频次学科排名<br> http://figure.impactfactor.cn/tcr/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases年度引用<br> http://figure.impactfactor.cn/ii/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases年度引用学科排名<br> http://figure.impactfactor.cn/iir/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases读者反馈<br> http://figure.impactfactor.cn/5y/?ISSN=BK0865372<br><br> <br><br>书目名称Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases读者反馈学科排名<br> http://figure.impactfactor.cn/5yr/?ISSN=BK0865372<br><br> <br><br>
使纠缠
发表于 2025-3-21 23:32:19
Introduction,rrent therapeutic approaches. In addition, pyrrole-imidazole polyamides, a class of DNA-binding ligands with sequence programmability, are introduced as promising drug candidates to modulate DNA mutation and abnormal RNA transcription.
得意牛
发表于 2025-3-22 01:17:52
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Lamina
发表于 2025-3-22 08:10:36
Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-Arginine vector improves biological activity of PIPs and PIP–tri-arginine conjugates achieve efficient transcription inhibition of SOX2-downstream genes in induced pluripotent stem (iPS) cells and . oncogene in human breast cancer cells. This simple vector expands the application of long PIPs by overcoming the compound delivery problems.
Kindle
发表于 2025-3-22 11:00:52
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Constitution
发表于 2025-3-22 15:31:18
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Compassionate
发表于 2025-3-22 20:18:25
Introduction,ut mitochondria also act as hubs for biosynthesis and metabolic waste management and as balancers to maintain cellular homeostasis. Due to the central role in cells, defects in mitochondrial function cause a critical impact on our body, making mitochondrion an attractive target for therapeutic purpo
pancreas
发表于 2025-3-23 00:26:55
Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Traelation between mitochondrial genome and diseases. In this chapter, a new type of synthetic DNA-binding ligands, termed MITO-PIPs, was developed by conjugating a mitochondria-penetrating peptide with pyrrole-imidazole polyamides (PIPs). A MITO-PIP that inhibits the binding of mitochondrial transcrip
Laconic
发表于 2025-3-23 01:23:52
Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation d from cells, no chemical-based drugs in clinical trials have the potential to modulate mtDNA mutation and cure mitochondrial diseases permanently. To achieve selective elimination of mitochondrial DNA with mutant adenine base, I develop a conjugate of MITO-PIP and chlorambucil (Chb), which can alky
肥料
发表于 2025-3-23 07:40:28
Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-Arginine hes utilizing pyrrole-imidazole polyamides (PIPs) have potential to modulate nuclear DNA transcription and replication based on DNA sequence information, their application in living cells has achieved limited success due to the moderate or poor nuclear accumulation of PIPs. In this chapter, I show t