INTER
发表于 2025-3-23 12:54:19
The Role of APC E3 Ubiquitin Ligase Complex in Tumorigenesis,08), while the overexpression of Cdc20 is observed in human malignancies (Mondal et al., Carcinogenesis 28(1):81–92, 2007; Jiang et al., Biochem Biophys Res Commun 415(2):325–329, 2011; Rajkumar et al., BMC Cancer 11:80, 2011; Chang et al., J Hematol Oncol 5:15, 2012; Kato et al., J Surg Oncol 106(4
fastness
发表于 2025-3-23 17:50:37
Conclusions and Research Perspectives,ategies to efficiently identify novel substrates for each E3 ligase, and to establish additional genetically engineered mouse models, both of which would greatly facilitate our understanding of the physiological as well as pathological roles of SCF and APC in tumorigenesis (Fig. 6.1).
某人
发表于 2025-3-23 18:34:42
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推延
发表于 2025-3-23 22:47:55
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tic-douloureux
发表于 2025-3-24 06:01:46
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dysphagia
发表于 2025-3-24 08:35:36
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Perceive
发表于 2025-3-24 13:33:11
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或者发神韵
发表于 2025-3-24 16:24:20
Book 2014mor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key c
recession
发表于 2025-3-24 21:29:07
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refraction
发表于 2025-3-25 01:58:54
Introduction,ulated responses to physiological cues that regulate normal cellular processes including proliferation, survival, and differentiation. Intensive investigations over the past decades have demonstrated that cancer can be considered largely a genetic disease, and typically multiple genetic alteration e