Clinton 发表于 2025-3-21 17:48:32
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Rho-modifying C3-like ADP-ribosyltransferases,uctures of C3 exoenzymes are available, allowing novel insights into the structure-function relationships of these exoenzymes. Because ADP-ribosylation specifically inhibits the biological functions of the low-molecular mass GTPases, C3 exoenzymes are established pharmacological tools to study the c和蔼 发表于 2025-3-22 12:38:15
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CNF and DNT,ne cells, phagocytosis by macrophages, secretion of cytokines, maintenance of epithelial barrier functions and others. With respect to these functions, it is not surprising that many bacterial protein toxins, which are important virulence factors and causative agents of human and/or animal diseases,admission 发表于 2025-3-22 17:16:23
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ExoS and ExoT,al ADP-ribosylation domains. The Rho GAP activities of ExoS and ExoT appear to be biochemically and biologically identical, targeting Rho, Rac, and Cdc42. Expression of the RhoGAP domain in mammalian cells results in the disruption of the actin cytoskeleton and interference of phagocytosis. Expressi影响带来 发表于 2025-3-23 02:37:07
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