amygdala
发表于 2025-3-26 22:44:23
Clinical Relevance of Multidrug-Resistance-Proteins (MRPs) for Anticancer Drug Resistance and Progny of multidrug transporters belong to the Multidrug Resistance Protein (MRP) family, also known as the ABCC family, which includes MRP1–9. These proteins are typically found in the plasma membrane of cells, where they efflux a broad range of both physiological substrates and xenobiotics, including a
abject
发表于 2025-3-27 03:39:26
Role of Breast Cancer Resistance Protein (BCRP, ABCG2) in Cancer Outcomes and Drug Resistance,ant role in altering absorption, distribution, metabolism, and excretion (ADME) of most extant and emerging molecular cancer therapeutics. BCRP expressed by neoplastic cells may also contribute to the resistance of these cells to chemotherapeutic agents. Although the expression of BCRP in human canc
magnate
发表于 2025-3-27 07:14:27
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Geyser
发表于 2025-3-27 10:35:54
ATP Binding Cassette Transporters in Cancer Stem-Like Cells,ing and sustaining the growth of a tumor, being responsible for tumor initiation, invasive growth, metastasis, and drug resistance. The isolation of CSC is not easy to achieve due to the need for proving phenotypic and functional features; thus, under many circumstances “putative CSC” is the most ap
里程碑
发表于 2025-3-27 14:16:46
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可忽略
发表于 2025-3-27 19:13:48
Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Synthetic and Phytochemical Small Moluring the past three decades, many efforts have been spent to develop strategies to overcome multidrug resistance. Many chemical compounds have been shown to inhibit the drug efflux of the multidrug-resistance-mediating P-glycoprotein. Chemical P-glycoprotein inhibitors are from the classes of calci
ASSET
发表于 2025-3-28 00:45:27
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GRIPE
发表于 2025-3-28 03:51:01
The Role of ABC Multidrug Transporters in Resistance to Targeted Anticancer Kinase Inhibitors,ted kinase inhibitors (TKIs), which are specifically capable of eliminating key pathways driving cancer growth and metastasis, are also applied in cancer treatment. The hydrophobic TKI molecules need to pass the cell membrane to reach their intracellular targets, and in many cases become substrates
使厌恶
发表于 2025-3-28 08:32:44
Nanotechnology to Combat Multidrug Resistance in Cancer,involving abnormal vasculature, localized area of hypoxia, upregulated ABC transporters, aerobic glycolysis, elevated apoptotic threshold, and increased interstitial fluid pressure. Nanomedicines in targeted cancer chemotherapy hold great promise as an effective approach to prevail over MDR. Extensi
affluent
发表于 2025-3-28 10:39:36
Drugs Affecting Epigenetic Modifications of ABC Transporters for Drug Resistance,een found to extrude anticancer drugs from the inside of the cells to their outside for the protection of the cells from the drugs, resulting in the drug resistance. However, the mechanisms of how cancer cells acquire ABC transporter-mediated drug resistance have not yet been fully understood. There