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The Nature of Endothelium-Derived Relaxing Factor,). Initial investigations into the mechanisms by which the phenomenon occurred suggested that it was mediated by a humoral agent, on the basis of “sandwich” experiments in which an aortic strip with intact endothelium could be shown to relax a closely apposed strip in which the endothelium had been
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Metabolism of Arachidonic Acid and Release of Endothelium-Derived Relaxing Factors, in vitro relaxation of vascular smooth muscle by acetylcholine. Subsequently, numerous other vasodilating substances have been found to have complete or partial endothelium dependence, and the term “endothelium-derived relaxing factor” (EDRF) was coined for the putative mediator of relaxation (Furc
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Release of Endothelium-Derived Relaxing Factor(s) by Physicochemical Stimuli, significant part, one would expect a continuous basal release of endothelium-derived vasoactive compounds, which would be effectively modulated or amplified by a number of physiological activators like metabolites, changes in PO. and PCO. (or pH), and similar parameters affected by increased activi
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in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the978-1-4612-8939-5978-1-4612-4588-9
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T. M. Cocks,J. A. Angus,J. H. Campbell,G. R. Campbell