讲个故事逗他
发表于 2025-3-27 01:00:15
http://reply.papertrans.cn/83/8257/825656/825656_31.png
外表读作
发表于 2025-3-27 02:12:16
Book 2020athways are still in their infancy. ..To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune che
禁止
发表于 2025-3-27 07:22:48
http://reply.papertrans.cn/83/8257/825656/825656_33.png
SOBER
发表于 2025-3-27 09:40:44
Molecular and Cellular Functions of CTLA-4,T-cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively. Because of its dampening effect, CTLA-4 is a crucial regulator of T-cell homeostasis and sel
钢盔
发表于 2025-3-27 14:19:08
Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond,eceptors expressed on T cells upon T cell activation. After engagement with its ligands, mainly PD-L1, PD-1 is activated and recruits the phosphatase SHP-2 in proximity to T cell receptor (TCR) and CD28 signaling. This event results in dephosphorylation and attenuation of key molecules in TCR and CD
indignant
发表于 2025-3-27 18:25:44
Discovery of New Immune Checkpoints: Family Grows Up,ll 2019 Q1, there are nine ICIs landing the oncology market: Ipilimumab (anti-CTLA-4, Bristol-Myers Squibb), Nivolumab (anti-PD-1, Bristol-Myers Squibb), Pembrolizumab (anti-PD-1, Merck), Atezolizumab (anti-PD-L1, Roche/Genentech), Durvalumab (anti-PD-L1, Astra Zeneca), Tremelimumab (anti-CTLA-4, As
闹剧
发表于 2025-3-28 00:33:51
http://reply.papertrans.cn/83/8257/825656/825656_37.png
西瓜
发表于 2025-3-28 04:10:04
http://reply.papertrans.cn/83/8257/825656/825656_38.png
stratum-corneum
发表于 2025-3-28 06:41:16
Rational Discovery of Response Biomarkers: Candidate Prognostic Factors and Biomarkers for Checkpoie. However, response rate of this promising therapy is low, thus requiring biomarkers for precise medication to reduce the ineffective treatment. With multiple retrospective clinical studies, more and more candidate prognostic factors have been identified with possible mechanic explanation, includin
数量
发表于 2025-3-28 10:49:37
http://reply.papertrans.cn/83/8257/825656/825656_40.png