地牢
发表于 2025-3-23 10:18:47
http://reply.papertrans.cn/83/8217/821689/821689_11.png
dermatomyositis
发表于 2025-3-23 17:39:34
http://reply.papertrans.cn/83/8217/821689/821689_12.png
清真寺
发表于 2025-3-23 20:02:13
http://reply.papertrans.cn/83/8217/821689/821689_13.png
豪华
发表于 2025-3-24 01:05:36
dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radi
尽管
发表于 2025-3-24 02:26:20
http://reply.papertrans.cn/83/8217/821689/821689_15.png
indoctrinate
发表于 2025-3-24 08:21:58
Introduction,dexrazoxane (ICRF-187) which are the subject of this book. Their history dates back to 1965 and gradually revealed a variety of modes of action which are as unexpected as they are unique – at present. The influence of razoxane and dexrazoxane on the differentiation of a pathologic neovasculature of
Cloudburst
发表于 2025-3-24 13:25:21
Razoxane,mmarized, e.g. the block of the cell cycle in the G2/M phase, the antimetastatic and antiinvasive activity, the ability to normalize pathological tumor blood vessels, the inhibition of topoisomerase II α, and the metal chelating activity. These activites are associated with a marked radiosensitizati
集聚成团
发表于 2025-3-24 14:52:48
Dexrazoxane,. Dexrazoxane has two potential pharmacological activities: it is a prodrug that is hydrolyzed to an iron chelating EDTA-type structure, and it is also a strong inhibitor of topoisomerase II. The anthracycline doxorubicin is able to be reductively activated to produce damaging reactive oxygen specie
Headstrong
发表于 2025-3-24 20:58:25
Summary and Outlook,antiinvasive activity in preclinical experiments, and they are able to normalize pathological tumour blood vessels. In addition, the drugs inhibit topoisomerase II α (the full implications have yet to emerge) and they are powerful chelating agents which not only chelate iron, but also a variety of o
Lacunar-Stroke
发表于 2025-3-25 01:31:49
Introduction,s an impressive cytoprotective activity in mitigating accidental anthracycline extravasation. In retrospect, the history of the two drugs justifies random screening as a valid method for the discovery of novel and effective drugs.