Antecedent
发表于 2025-3-28 15:45:17
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muscle-fibers
发表于 2025-3-28 19:00:23
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EVICT
发表于 2025-3-29 02:57:49
The Human Exosome and Disease,we will describe the identification of the PM/Scl autoantigen from a historical perspective, discuss our current knowledge on the occurrence of autoantibodies to exosome components in autoimmune diseases and end with the data that connect the exosome with cancer.
公猪
发表于 2025-3-29 06:09:39
Catalytic Properties of the Eukaryotic Exosome,onucleolytic one. Rrp6 proteins are distributive exonucleases. This chapter will review the current knowledge about the catalytic properties of theses nucleases and their interplay within the exosome holocomplex.
异教徒
发表于 2025-3-29 08:42:59
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exacerbate
发表于 2025-3-29 13:47:38
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FIS
发表于 2025-3-29 16:44:30
Structural Components and Architectures of RNA Exosomes,ubstrates by the RNA exosome. This chapter will focus on the structural organization of eukaryotic exosomes and their evolutionary cousins in bacteria and archaea with an emphasis on mechanistic details related to substrate recognition and to 3′ to 5′ phosphorolytic exoribonucleolytic activities of
的事物
发表于 2025-3-29 21:10:03
The Archaeal Exosome, alternating Rrp41 and Rrp42 polypeptides, arranged in a hexameric ring. A flexible RNA binding cap composed of the evolutionarily conserved proteins Rrp4 and/or Csl4 is bound at the top of the ring and seems to be involved in recruitment of specific substrates and their unwinding. Additionally, the
果核
发表于 2025-3-30 02:52:07
The Exosomes of Trypanosomes and Other Protists,omain proteins. In animals and yeast, six different, but related subunits form the RNase PH-like core, but these lack enzyme activity; there are three different Si-domain proteins and enzyme activity is provided by the endo/exonuc lease Rrp44 or—mainly in the nuclear exosome—the Rnase D enzyme Rrp6.
ANNUL
发表于 2025-3-30 05:23:47
,The Exosome and 3′–5′ RNA Degradation in Plants,plex, which associates with active ribonucleases, RNA binding proteins, helicases and additional co-factors. While yeast and human exosome core complexes are catalytically inactive, the plant core complex has probably retained a phosphorolytic activity. Intriguingly, the down-regulation of individua