hypnogram
发表于 2025-3-28 14:35:56
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INERT
发表于 2025-3-28 21:25:23
Quantitative Determination of Intracellular Bond Cleavagey systems, which drives the subcellular localization and processing of therapeutic cargo. With numerous stimuli-responsive drug delivery systems in development, a quantitative measurement of their intracellular processing is of paramount importance. In this chapter, we discuss methods for determinin
抛射物
发表于 2025-3-29 00:03:40
Development and Application of a Single Cell-Level PK-PD Model for ADCsonents (i.e., antibody, linker, and payload). Pharmacokinetic and pharmacodynamic (PK-PD) modeling and simulation is a powerful tool that can help with this process. It provides a rigorous understanding of how each ADC-related component impacts whole-body disposition and pharmacology of ADCs, and fa
沙漠
发表于 2025-3-29 06:17:23
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恩惠
发表于 2025-3-29 08:32:38
Tracking siRNA–Nanocarrier Assembly and Disassembly Using FRETt guarantee the incorporation of the nucleic acid into nanosized particles, followed by efficient cellular uptake, resistance to the changing physicochemical environment during endolysosomal trafficking and finally the adequate release of its payload in the cytosol of the cell. While the outcome of
激怒
发表于 2025-3-29 14:44:39
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上流社会
发表于 2025-3-29 16:42:35
les in transit. Brain fluids (CSF and brain interstitial fluid) are secreted, flow through particular routes and then drain back into the venous system; this fluid turnover aids central homeostasis and also affects CNS drug concentration. Several CNS pathologies involve changes in the barrier layers
细颈瓶
发表于 2025-3-29 23:10:19
Kyoung Ah Min,Gus R. Rosaniales in transit. Brain fluids (CSF and brain interstitial fluid) are secreted, flow through particular routes and then drain back into the venous system; this fluid turnover aids central homeostasis and also affects CNS drug concentration. Several CNS pathologies involve changes in the barrier layers
exhibit
发表于 2025-3-30 00:04:07
Joe Bentz BBB model cell lines, which also introduces methodologies for plasma membrane preparations. The expression profile of membrane proteins in cultured cells provides helpful information and new insights for assessing such cells, particularly for in vitro BBB model systems.
forthy
发表于 2025-3-30 06:26:15
Jibin Li,Qing Wang,Ismael J. HidalgoElectron microscopy indicated FUS activated trans-cellular transport, and reversibly affected tight junctions. Transient disruption of the BBB allowed delivery of both small-molecule drugs (Doxorubicin) and large-molecule antibody-based chemotherapeutic (Herceptin). The FUS-induced BBB disruption al