珠宝
发表于 2025-3-23 09:48:38
Orotic Acid in Human Therapylearance of orotic acid approaches that of creatinine , and during drug-induced orotic aciduria it exceeds glomerular filtration . There is evidence that even high doses of orotic acid are not deleterious to human individuals except that they may occasionally obstruct urine flow by forming crystalline deposits .
PUT
发表于 2025-3-23 14:34:37
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有帮助
发表于 2025-3-23 18:58:25
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冷峻
发表于 2025-3-23 23:42:31
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nitric-oxide
发表于 2025-3-24 05:29:20
New Growth Factor?ommercial powdered milk have a relatively high content of orotic acid (50–100 mg 1. and 100–130 mg per 100 g protein respectively) human milk contains only trace amounts of orotic acid . Its concentration in other foods is not yet known. There are several reports dealing with the amount of
PALSY
发表于 2025-3-24 08:28:20
Aggregation of Enzymes of the Orotate Pathwayase activity. Also under a variety of physiological conditions both enzymes show closely parallel, co-ordinate changes in activity . Orotate phosphoribosyltransferase from murine leukaemia P 1534 J (utilizing as the substrate orotate and 5-fluorouracil) was found to exist as a complex with
昏睡中
发表于 2025-3-24 10:49:55
Efficiency and Regulation of Pyrimidine Synthesis than 90-fold by a combination of PRPP and a heat labile factor , probably orotate phosphoribosyltransferase. It is assumed that the enzyme attaches to the cell membrane and in the presence of external orotic acid and PRPP leads to the formation of internal orotidine 5′-phosphate. In bact
gospel
发表于 2025-3-24 18:28:19
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陈腐的人
发表于 2025-3-24 20:22:23
Inhibitors of the Orotate Pathwayacts as a competitive inhibitor of orotidylic acid decarboxylase . Therapeutic use of 6-azauridine is occasionally complicated by a pronounced crystalluria. Owing to the block of orotidylic acid decarboxylase, large amounts of orotidine and orotic acid are excreted in urine. After the
omnibus
发表于 2025-3-25 00:07:54
Induction of Fatty Liver in Ratsct is species specific and does not seem to occur in humans. The deposition of triglycerides in the liver, accompanied by a decrease in the concentration of plasma lipids, is a common and characteristic feature of fatty liver induced by various drugs. The earliest biochemical change detect