Interjection 发表于 2025-3-21 17:10:53
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Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Druhelia, OCT2 mediates uptake of the drugs such as metformin or cimetidine at basolateral membrane, and MATE1 and MATE2-K mediated the secretion of cationic and zwitterionic drugs at brush-border membrane. In the liver, OCT1 are expressed on the sinusoidal membrane and MATE1 are expressed on the canalCriteria 发表于 2025-3-22 07:50:40
Genetic Variability in Organic Cation Transporters: Pathophysiological Manifestations and Consequen of plasma and organ concentrations of endogenous molecules and drugs. Hence, genetic variants in the organic cation transporters may confer susceptibility to diseases and may cause variations in drug pharmacokinetics, efficacy and toxicity..This chapter gives a structured overview of the genetic vareceptors 发表于 2025-3-22 11:17:15
Physiological and Pathophysiological Regulation of Transporters for Organic Cations,oss plasma membranes in a driving force dependent and saturable manner. These transporters are responsible for the cellular uptake and extrusion of many cationic drugs and toxins and therefore prerequisite for their metabolism, therapeutical actions, but also for their negative side effects. Togetheexplicit 发表于 2025-3-22 13:46:39
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