nutrition
发表于 2025-3-28 17:26:58
The Application of Multivariate Data Analysis to Compound Property Optimization,ermeability, and metabolic stability of compounds need to be optimized simultaneously with potency, functional activity, cellular activity, selectivity and other biological parameters. However, the data from all of these assays for the numerous compounds prepared by parallel synthesis makes the inte
NIB
发表于 2025-3-28 19:07:23
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无瑕疵
发表于 2025-3-29 01:29:02
Predicting Idiosyncratic Drug Reactions,omic cost and patient burden. Although our understanding of IDR continues to grow, our ability to predict and avoid these reactions remains unacceptably poor. The intent of this chapter is to review approaches that may be used during lead optimization to minimize the likelihood of producing compound
衍生
发表于 2025-3-29 04:12:33
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prostatitis
发表于 2025-3-29 09:33:46
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看法等
发表于 2025-3-29 12:47:00
Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimizatidelivery to CNS targets, brain exposure is considered for unwanted CNS access for either on-target activity or for off-target CNS toxicity or adverse events. The biopharmaceutical scientist is challenged to arrive at a rational strategy that is functional within the constraints of limited resources.
arousal
发表于 2025-3-29 19:34:02
Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Develouce the risk of drug failure after long, expensive clinical development programs, accurate information is required about the biological effects of the compounds being tested. Therefore, there is a strong need for biomarkers that can assist in unraveling the complex biology of these novel drug target
被诅咒的人
发表于 2025-3-29 23:43:10
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失败主义者
发表于 2025-3-30 03:03:40
result of more than six years of hard work by a dedicated group of European urban forest and tree experts. The editors are indebted to the national experts of COST Action E12 ‘Urban Forests and Trees’ and to the others who have contributed to the various chapters in this publication. Ultimately, 59
死亡率
发表于 2025-3-30 05:47:33
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