向外 发表于 2025-3-27 00:34:31

Strategic Use of Preclinical Pharmacokinetic Studies and , Models in Optimizing ADME Properties of e initiation or progression of the disease. Because abnormally high or low activity of proteins (receptors, enzymes, or transporters) or of the genes that code for these proteins is the underlying cause of most diseases, therapeutic intervention requires modulation of the target protein or gene acti

prosperity 发表于 2025-3-27 01:55:26

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内行 发表于 2025-3-27 05:40:46

Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions,divided into acute, dose dependent reactions (Type A), and reactions that may occur in only a small percentage of patients, where the frequency of occurrence in the population is not dependent on dose (Type B), although more complex classifications have also been proposed, (.). According to a recent

chapel 发表于 2025-3-27 12:08:28

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invert 发表于 2025-3-27 17:06:46

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Hypomania 发表于 2025-3-27 19:27:58

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责任 发表于 2025-3-27 22:49:00

Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure,cy models, and evaluate toxicity. Poor exposure can lead to highly variable data, and/or ambiguous study results. Use of resource and scarce API for uninterpretable study outcomes is highly inefficient, and based on poor data, a compound may be given an undeservedly low priority. Because exposure is

Ringworm 发表于 2025-3-28 02:32:32

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faddish 发表于 2025-3-28 09:56:09

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轻浮思想 发表于 2025-3-28 13:25:12

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查看完整版本: Titlebook: Optimizing the "Drug-Like" Properties of Leads in Drug Discovery; Ronald T. Borchardt,Edward H. Kerns,James L. Steve Book 2006 Springer-Ve