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Basics of Molecular Biology for Next-Generation Sequencingdequate introduction to the subject. These basics would greatly aid a lay audience in understanding this and other computational biology resources and textbooks. Readers with a firm biological background may choose to skip this chapter.
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Challenges in the Next-Generation Sequencing Fieldst few years. We have previously described how next-generation sequencing has advanced DNA sequencing from low throughput to high throughput and minimized labor-intensive practices to more automated processes. In this chapter, we will compare next-generation sequencing with the traditional Sanger me