心痛 发表于 2025-3-28 16:28:27
https://doi.org/10.1007/978-94-011-5386-7Prostaglandin; cancer; cytokine; inflammation; research厌食症 发表于 2025-3-28 19:26:23
The history of anti-inflammatory drugs and their mechanism of action, salicylates are constituents of several plants long used as medicaments. About 3500 years ago the Egyptian Ebers papyrus recommended the application of a decoction of the dried leaves of myrtle to the abdomen and back to expel rheumatic pains from the womb. A thousand years later Hippocrates recomm健忘症 发表于 2025-3-28 23:12:22
http://reply.papertrans.cn/67/6658/665791/665791_43.png外貌 发表于 2025-3-29 06:35:39
Differential inhibition of cyclooxygenases 1 and 2 by NSAIDs,onstration that inhibition of prostanoid synthesis through cyclooxygenase blockade is the mechanism of action of aspirin and related NSAIDs., it had been widely accepted that a common mechanism of action can explain both therapeutic and side effects of NSAIDs (Figure 1). The discovery of two isoform压舱物 发表于 2025-3-29 09:47:47
http://reply.papertrans.cn/67/6658/665791/665791_45.png使迷惑 发表于 2025-3-29 12:32:19
Brain COX-2 in experimental models of epilepsy and stroke: signalling pathways leading to enhanced ucts such as arachidonic acid., diacylglycerols. and platelet-activating factor (PAF)., increased glutamate release, and elevation of intracellular free calcium levels. Phospholipase activation and the release of bioactive lipids from membrane phospholipid pools represent part of an intrinsic neural倔强一点 发表于 2025-3-29 19:32:58
New highly selective cyclooxygenase-2 inhibitors,yme) and COX-2 (inducible enzyme).. COX-1 has been cloned from a number of sources including mouse, man and sheep.. COX-2 was originally identified as a v-.-inducible gene product in chicken fibroblasts and as a phorbol ester-inducible early gene product in murine 3T3 cells.. These proteins were recpus840 发表于 2025-3-29 20:39:11
http://reply.papertrans.cn/67/6658/665791/665791_48.pngd-limonene 发表于 2025-3-30 02:00:42
X-ray crystal structure of human cyclooxygenase-2, through inhibition of the enzyme prostaglandin H synthase., also referred to as cyclooxygenase (COX). The discovery of an inducible COX enzyme (COX-2), distinct from the constitutively expressed enzyme (COX-1)., has led to the suggestion that a new generation of safer NSAIDs may be developed in the规章 发表于 2025-3-30 06:00:37
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