无法治愈 发表于 2025-3-23 10:55:48
http://reply.papertrans.cn/67/6658/665791/665791_11.pngbiopsy 发表于 2025-3-23 16:38:03
Blockade of inflammatory hyperalgesia and cyclooxygenase-2,tentiates the intraplantar effect of IL-l. or carrageenan, suggesting that induction of COX-2 is a limiting process in the development of inflammatory hyperalgesia. Induction of COX-2 is typically inhibited by corticosteroids. In our system IL-1. -induced hyperalgesia is inhibited by dexamethasone t要控制 发表于 2025-3-23 18:23:26
Brain COX-2 in experimental models of epilepsy and stroke: signalling pathways leading to enhanced s. BN 50730, an intracellular PAF antagonist., blocks PAF-induced COX-2 expression. We therefore tested the effectiveness of BN 50730 in blocking induction of COX-2 mRNA and protein expression in vivo. The two models used were focal cerebral ischaemia using the suture model of middle cerebral artery薄荷醇 发表于 2025-3-23 23:14:33
New highly selective cyclooxygenase-2 inhibitors,ning the protein in the endoplasmic reticulum. The main significant difference between COX-2 and COX-1 is that COX-2 can be induced transiently over a >50-fold range by a variety of agents, including cytokines, phorbol esters, hormones, serum and lipopolysaccharide. This induction can be inhibited b群居男女 发表于 2025-3-24 05:15:47
http://reply.papertrans.cn/67/6658/665791/665791_15.png先驱 发表于 2025-3-24 10:02:58
Clinical experience with meloxicam, a selective COX-2 inhibitor,e NSAIDs are selective for COX-1 or are equipotent against both COX-1 and COX-2. NSAIDs such as meloxicam, which are more selective for COX-2 than for COX-1, have been developed and are efficacious in the treatment of rheumatic disease. Drugs which are highly selective for COX-2 are presently being阴谋小团体 发表于 2025-3-24 13:16:48
http://reply.papertrans.cn/67/6658/665791/665791_17.png不能平静 发表于 2025-3-24 16:14:33
http://reply.papertrans.cn/67/6658/665791/665791_18.pngepicardium 发表于 2025-3-24 22:02:21
in clinical trials gastric and renal toxicities are less. Highly selective COX-2 inhibitors, perhaps designed with knowledge of the crystal structures of COX-I and COX-2, are also available. Other experimental studies, including those in animals lacking effective genes for COX-lor COX-2 and in experimental c978-94-010-6265-7978-94-011-5386-7macrophage 发表于 2025-3-25 00:28:28
http://reply.papertrans.cn/67/6658/665791/665791_20.png