frustrate 发表于 2025-3-21 18:54:41
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Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging the information gained from animal studies will extend to humans. However, a fundamental difference must exist between human and rodents in terms of neoplastic development because cancers generally arise in rodents after a few years whereas the same cancers require decades in humans. For example, t哑巴 发表于 2025-3-22 04:28:24
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Use of Immortalized Human Keratinocytes for the Study of Squamous Differentiation and Mutagenesis system for quantification of DNA damage at a defined genetic locus and 2) determine new epithelial-specific phenotypes associated with malignant conversion. HK lines RHEK-1 and HPK-1A were established by immortalization by a hybrid of adenovirus 12 and simian virus 40 (Ad12-SV40) (1) or human papil外貌 发表于 2025-3-22 09:50:26
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Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K-, though the specific role of these amines is still not well understood at the molecular level, recent studies have shown that their concentration is highly regulated and that polyamines are necessary for normal cell growth and differentiation (see reviews 1 – 3). The pathway of polyamine biosynthesisagenda 发表于 2025-3-23 00:51:17
Transformation of Human Diploid Fibroblasts by Radiation and Oncogenestransformation .. Whether the progeny of this cell will eventually give rise to an invasive, malignant tumor depends upon a number of host and tissue factors. The malignant transformation of cells . is also a complex, multi-step process by which normal cells acquire the various phenotypic characteri期满 发表于 2025-3-23 04:36:05
Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expressiont. Genes encoding transcription factors are expressed immediately after x-ray exposure in the absence of de novo protein synthesis. c-., c-. and Egr-1 are expressed following irradiation of human normal tissue cells and tumor cell lines. Radiation-mediated expression of these immediate early genes i弄脏 发表于 2025-3-23 05:33:27
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