breadth 发表于 2025-3-28 16:37:16
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Book 1989gents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino glycosides etc. In this book many of the authors were asked to emphasize the mechanism of resistance in their discussion and from that to show how susceptibility to various agents was affected. In part this wasNAV 发表于 2025-3-29 07:06:18
Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance, same time it produced an increase in infections, often hospital-acquired, by antibiotic-resistant gram-negative bacteria of moderate or even marginal pathogenicity (. 1985). The general resistance to antibiotics, often encountered in such gram-negative bacteria, is largely due to the presence of an不规则 发表于 2025-3-29 08:01:12
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Resistance to ,-Lactam Antibiotics Mediated by Alterations of Penicillin-Binding Proteins, lipid-linked disaccharide-pentapeptide substrate of the enzymes that catalyse the synthesis of crosslinked peptidoglycan (. and . 1983). These enzymes can be detected and studied as penicillin-binding proteins (PBPs) as they are essentially irreversibly acylated by penicillin, and other .-lactam an公共汽车 发表于 2025-3-29 16:41:07
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Beta-Lactamases: Genetic Control,ere discovered as early as 1940, when an extract of a strain of . was shown to inactivate a solution of benzylpenicillin (. et al. 1940). A few years later the importance of beta-lactamases was demonstrated in gram-positive bacteria when . producing such an enzyme was shown to be responsible for cliBasilar-Artery 发表于 2025-3-30 05:32:55
Resistance to Quinolones and Fluoroquinolones,r agents nalidixic and oxolinic acid. The quinolone class (which includes 4-pyridone antibacterials) share the 4-quinolone nucleus and also a carboxylic acid substituent at position 3 (Fig. 1). During the last twenty-five years many compounds have been synthesised with additional substituents upon t