Favorable
发表于 2025-3-26 21:11:56
Structure and Regulation of EAL Domain Proteinsgulation and has provided novel insight into the enzymatic reaction mechanism. Several regulatory layers may control activity, including dimerisation, active site formation, and metal coordination. In this review, we provide a concise summary of these exciting findings and highlight open research qu
出血
发表于 2025-3-27 03:57:42
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软弱
发表于 2025-3-27 07:24:45
Structure and Function of HD-GYP Phosphodiesterasesred into two distinct groups depending on the metal binding site, which can accommodate two or three metal ions. The nature and the number of bound metals determine whether a certain HD-GYP will be active as a PDE or will function as a dinucleotide binding domain. In this chapter, we will review the
LOPE
发表于 2025-3-27 13:13:53
A Unified Catalytic Mechanism for Cyclic di-NMP Hydrolysis by DHH–DHHA1 Phosphodiesterasesears. According to detailed structural and enzymatic analyses, we have summarized a unified molecular mechanism for the DHH–DHHA1 PDEs and systematically analyzed the catalytic activities of DHH–DHHA1 PDEs on other cyclic di-NMPs (cyclic di-GMP and cGAMP).
切割
发表于 2025-3-27 15:09:49
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固执点好
发表于 2025-3-27 21:50:21
Detection of Cyclic Dinucleotide Binding Proteinss, the field has revealed that cyclic di-GMP directly regulates many cellular functions through allosteric binding. Despite the success in the field of identifying protein receptors in the past few decades, cyclic dinucleotide receptors often can only be experimentally identified due to their divers
Silent-Ischemia
发表于 2025-3-27 23:11:39
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生存环境
发表于 2025-3-28 02:30:56
Metabolic Regulation by Cyclic di-AMP Signalingonal levels, as well as the molecular mechanism of this regulation. We will highlight the regulation of central carbon metabolism through pyruvate carboxylase, the regulation of cell wall metabolism through the . riboswitch, and the impact on host cell inflammatory response through competitive inhib
synchronous
发表于 2025-3-28 09:59:42
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Transfusion
发表于 2025-3-28 14:04:33
Activation of Bacterial Cellulose Biosynthesis by Cyclic di-GMPtructural and functional characterizations of . cellulose synthase in resting and activated states provided unique insights into how cyclic di-GMP modulates enzymatic functions. This will be reviewed by discussing (1) biochemical analyses leading to cyclic di-GMP’s discovery and elucidation of its a