Confer 发表于 2025-3-21 18:45:05
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LITiCon: A Discrete Conformational Sampling Computational Method for Mapping Various Functionally Senal selective conformational states starting from the inactive state of the receptor..LITiCon has been applied to map the conformational ensemble of β2-adrenergic receptor, a class A GPCR. We have shown that β2-adrenergic receptor samples a larger conformational space in the ligand-free state and th广大 发表于 2025-3-22 05:35:55
Homology Model-Assisted Elucidation of Binding Sites in GPCRsach, (b) predicting potential binding pockets, (c) docking known binders, (d) analyzing predicted interactions and comparing with positions that have been shown to bind ligands in other receptors, (e) validating the structural model by mutagenesis.aesthetician 发表于 2025-3-22 12:40:19
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Book 2012nto the mechanism of the dynamics of membrane receptors. Written in the highly successful .Methods in Molecular Biology.™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory..Thorough and intuiti