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Genetic and Environmental Factors in Carcinogenesis,even when cultured or when injected in immunologically tolerant experimental animals (. and . 2000; . and . 1998). Yet, the views about the environmental (somatic) and inherited origin of the genetic alterations in human cancer have been debated and any reasonable agreement can be reached only when教育学 发表于 2025-3-22 01:19:59
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Signalling Pathways as Targets in Cancer Prevention,cell growth, or undergo apoptosis. Transformed cells either fail to respond or receive inappropriate signals which favor proliferation and avoidance of apoptosis. Thus, it is no coincidence that many oncogenes and tumor suppressor genes are components of signalling pathways. Despite the great variet植物学 发表于 2025-3-22 12:01:43
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Deficient DNA Mismatch Repair in Carcinogenesis,isincorporation during DNA synthesis. The genes coding for MMR proteins are highly conserved throughout evolution. The human proteins that correspond to the bacterial MutS proteins and participate in MMR include MSH2, MSH3, and MSH6, whereas the human MutL proteins include MLH1, PMS1, PMS2, and MLH3Adj异类的 发表于 2025-3-22 22:21:04
Epigenetic Changes, Altered DNA Methylation and Cancer,specialized chromatin structures are capable of stably modulating gene expression over many cell generations. Thus, an epigenetic mutation can have the same effect like a classical, genetic mutation, i.e., loss- or gain-of-function of any given gene. Sensitive methods for the detection of epigeneticButtress 发表于 2025-3-23 02:27:02
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