灿烂
发表于 2025-3-25 06:07:04
Callum A. MacDonaldy to accurately map and quantify RNA modifications. Modification-specific antibodies or modification-sensitive endonucleases coupled with short-read RNA sequencing technologies have allowed for low-resolution or limited mapping of important regulatory modifications of HIV RNA such as N.-methyladenos
IST
发表于 2025-3-25 09:47:17
Callum A. MacDonaldnd viral proteins, are essential for viral replication, whereas others, such as host innate immune proteins, can inhibit virus replication. Therefore, analyzing the virion content is an integral part of studying HIV-1 replication. Traditionally, virion contents have been examined using biochemical a
HACK
发表于 2025-3-25 11:49:10
Callum A. MacDonaldnd viral proteins, are essential for viral replication, whereas others, such as host innate immune proteins, can inhibit virus replication. Therefore, analyzing the virion content is an integral part of studying HIV-1 replication. Traditionally, virion contents have been examined using biochemical a
欺骗世家
发表于 2025-3-25 19:26:23
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acrobat
发表于 2025-3-25 21:23:08
Callum A. MacDonaldd an uninfected, CD4-expressing “target” cell. In vitro studies indicate that HIV-1 cell-to-cell infection is much more efficient than infection by cell-free viral particles; however, the exact mechanisms of the enhanced efficiency of this infection pathway are still unclear. Several assays have bee
紧张过度
发表于 2025-3-26 03:49:32
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拖债
发表于 2025-3-26 04:25:43
Callum A. MacDonaldric IN inhibitors or ALLINIs, which potently impair viral replication by promoting aberrant, higher order IN multimerization as well as inhibit IN interactions with its cellular cofactor, LEDGF/p75, has opened new venues to exploit IN multimerization as a therapeutic target. Furthermore, the recent
善于骗人
发表于 2025-3-26 08:33:11
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creatine-kinase
发表于 2025-3-26 15:01:28
Callum A. MacDonaldd an uninfected, CD4-expressing “target” cell. In vitro studies indicate that HIV-1 cell-to-cell infection is much more efficient than infection by cell-free viral particles; however, the exact mechanisms of the enhanced efficiency of this infection pathway are still unclear. Several assays have bee
宽敞
发表于 2025-3-26 20:29:17
troviruses can be complicated by the contamination of even highly purified virion preparations with nonviral particles (either microvesicles or exosomes). Two useful methods have been developed that can remove contaminating particles from virus stocks to produce highly pure virus preparations. One a