exceptional
发表于 2025-3-28 18:01:43
Günter Zepfphosphoprotein with two isoforms, p56 and p58 (the hyperphosphorylated form of p56) . Clinically, a close association was demonstrated between mutations in the NS5A gene of HCV-lb and the response to interferon-α in patients with chronic active hepatitis . Recently, the NS5A protein was show
Offstage
发表于 2025-3-28 19:03:53
Günter Zepfed the limitations of this first-generation DAA regimen, including activity that was limited to genotypes 1 and 4 and the need for ribavirin for some patients, which defined a target product profile for a next-generation regimen. This continued research and development activity ultimately led to the
Glucose
发表于 2025-3-29 00:24:05
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OPINE
发表于 2025-3-29 04:21:36
Günter Zepfr to SVR underwent a biopsy after SVR. However, the post-SVR liver biopsies of only 4 patients showed F1–F2, while 11 patients still showed F3–F4, indicating that TE improvements are overstated when compared to histologic staging and that patients with cirrhosis before DAA therapy need to be monitor
TATE
发表于 2025-3-29 09:38:02
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MARS
发表于 2025-3-29 13:01:52
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Noisome
发表于 2025-3-29 15:37:10
Günter Zepfpprovals include multiple third-generation cross-genotype active compounds that also have improved activity against key NS3/4a resistance mutations at A156, R155, and D168. These compounds, including grazoprevir, glecaprevir, and voxilaprevir, can be used in interferon/ribavirin-free, direct-acting
critic
发表于 2025-3-29 21:13:47
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AMPLE
发表于 2025-3-30 00:56:58
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水獭
发表于 2025-3-30 07:26:31
Günter Zepfand triphosphate. Both PSI-6130 triphosphate and PSI-6206 triphosphate were shown to be potent alternative substrate inhibitors of the HCV NS5B polymerase. Because the triphosphate of PSI-6206 was a potent inhibitor of the NS5B polymerase and because it had a long intracellular half-life, the goal w