ominous 发表于 2025-3-21 18:17:45
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Günter Zepfed for the treatment of genotype 1 HCV infection. The research and development team at Abbott/AbbVie based their approach to HCV cure on the use of three DAAs to avoid emergence of resistance, anchored by a potent protease inhibitor and NS5A inhibitor. Clinical trials were designed to answer multiplFillet,Filet 发表于 2025-3-22 04:53:58
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Günter Zepfipasvir and the nonstructural 5B protein (NS5B) nucleotide inhibitor sofosbuvir (SOF), provided a major advancement in the treatment of individuals with chronic genotype 1 (GT1) HCV infection. Herein is described the discovery of velpatasvir (VEL, GS-5816), a pan-genotypic NS5A inhibitor with low pi偏离 发表于 2025-3-22 19:34:22
Günter Zepfe advanced liver disease. This has resulted in a reduced incidence of liver cancers and reduced liver-related mortality. Benefits of cure in patients without cirrhosis have not been seen yet in systemic review, but are likely to be seen in the future years. There remain unresolved issues regarding p外貌 发表于 2025-3-23 00:16:05
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Günter Zepft to understand basic HCV biology, which led to the development of HCV cell culture systems eventually enabling drug discovery. Initial studies focused on biochemical characterization of viral proteins and dissected their roles in the virus life cycle. Two of the viral proteins, NS3-4A protease andVulnerable 发表于 2025-3-23 09:19:57
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