Sarcoma
发表于 2025-3-26 20:58:27
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Host142
发表于 2025-3-27 01:29:49
Conference proceedings 2006...The state of our art also benefits by the availability of superior tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design..
通便
发表于 2025-3-27 05:36:21
Obesity-related mutations of leptin and melanocortin receptors,crine features of these mutations causing a dysfunction in leptin and melanocortin signaling will be reviewed. The contribution of genetic variations of genes encoding the key actors of the leptin andmelanocortin pathways in common forms of obesity will also be discussed.
轻快带来危险
发表于 2025-3-27 09:32:55
Conference proceedings 2006ase. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes w
鸽子
发表于 2025-3-27 15:42:52
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横截,横断
发表于 2025-3-27 18:11:00
A molecular dissection of the glycoprotein hormone receptors,om a tethered inverse agonist to a full agonist of the serpentine, rhodopsin-like portion of the receptor. Unexpectedly, the picture is complicated by the observation that promiscuous activation of one of the receptors (FSHr) by hCG or TSH can result from activating mutations affecting the serpentine portion of the receptors.
母猪
发表于 2025-3-28 01:47:51
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PANT
发表于 2025-3-28 04:26:20
1861-2253 r the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on resc
问到了烧瓶
发表于 2025-3-28 09:42:58
Functional Rescue of Misfolded Receptor Mutants,s that are misrouted in the cell. Such mutant receptors are retained in the endoplasmic reticulum and can be rescued by pharmacological chaperones. This understanding contrasts with the view that these mutant receptors lose the ability to bind ligand or effect signal transduction. Pharmacological ch
Measured
发表于 2025-3-28 14:08:10
Obesity-related mutations of leptin and melanocortin receptors,e rare mutations largely contribute to the development of some obesity cases. Research was conducted after a meticulous clinical evaluation of individuals with specific biochemical or hormonal anomalies. These obesity cases are very severe and generally start in childhood. This chapter will focus on