FLAGR 发表于 2025-3-23 13:32:44
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Biochemical Isolation of the Myddosome from Murine Macrophages,pathways essential for host defense. Despite their structural divergence, key signaling molecules in diverse innate immune pathways mediate signal transduction by assembling higher-order protein complexes at specific subcellular locations in a stimulus-dependent manner. These protein complexes are c大吃大喝 发表于 2025-3-24 01:01:10
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http://reply.papertrans.cn/47/4666/466582/466582_15.png下边深陷 发表于 2025-3-24 09:04:20
Inflammatory Caspases: Activation and Cleavage of Gasdermin-D In Vitro and During Pyroptosis,l inflammasome activation or caspase-4, 5, and 11 upon their ligation and activation by cytosolic LPS. Upon a single cleavage between the two domains in Gasdermin-D, the N-terminal domain binds to membrane lipids and lyses cells by forming pores of an inner diameter of 10–14 nm within the membrane.缺乏 发表于 2025-3-24 13:33:26
Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking,flammasomes. This unique feature of ASC allows its visualization by several imaging techniques and constitutes a reliable and feasible readout for inflammasome activation in cells and tissues. We have previously described step-by-step protocols to generate immortalized cell lines stably expressing ABricklayer 发表于 2025-3-24 15:15:27
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