钱财
发表于 2025-3-28 15:33:12
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贪婪地吃
发表于 2025-3-28 20:16:41
Protein Tyrosine Phosphatases as Therapeutic Targetsown propagation. Taken together, these findings identified specific PTPs as significant targets for the therapeutic intervention in human diseases. For instance, the discovery that PTP1B is a negative regulator of insulin signaling revealed that this molecule is an attractive target for the treatmen
Harness
发表于 2025-3-29 00:51:53
Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors indicating that PTP1B is an important negative regulator of insulin and leptin action and hence a potentially important drug target for the treatment of diabetes and obesity. The development of PTP inhibitors, in particular PTP1B inhibitors, has been greatly facilitated by an impressive number of X
不能逃避
发表于 2025-3-29 06:33:29
Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Targetlls that do exit to the periphery are markedly non-responsive to mitogens. The p56. kinase also has an activating autophosphorylation site that can be dephosphorylated by CD45 under some circumstances. However, the overall regulatory actions of CD45 on p56. function in the context of T cell antigen
Seizure
发表于 2025-3-29 10:12:05
Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimuscations outside the field of transplantation. Ciclosporin and tacrolimus are metabolised by cytochrome P450 3A and are substrates for the P-glycoprotein transporter system. This results in complex pharmacokinetics with large variations in bioavailability and metabolism between individuals as well as
Epithelium
发表于 2025-3-29 12:36:32
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BIPED
发表于 2025-3-29 18:52:08
Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Groressa-resistant tumours appeared during treatment, but some tumours regrew following drug withdrawal. The level of expression of EGFR did not determine xenograft tumour sensitivity to Iressa. These preclinical studies indicated the potential utility of Iressa in the treatment of a wide range of huma
发源
发表于 2025-3-29 21:28:43
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bromide
发表于 2025-3-30 02:08:20
M. Gaßel,C. Breitenlechner,S. Herrero,R. Engh,D. Bossemeyeregen scheint E. T. A. Hoffmanns berühmte Rezension zu Beethovens 5. Symphonie (1810) einen nahezu idealen Ausgangspunkt zu bieten. E. T. A. Hoffmann bezeichnet Beethoven nicht nur als einen „rein romantischen (…) Komponisten, dessen Musik „die Hebel des Schauers, der Furcht, des Entsetzens, des Schm
严厉批评
发表于 2025-3-30 06:08:54
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