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Overview of COX-2 in inflammation: from the biology to the clinic,hospholipids (principally, arachidonic acid) into prostanoids (prostaglandins and thromboxanes). Prostanoids contribute to diverse physiological and pathological processes including inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs), the prototype of which is aspirin, owe their therapeuticsultry 发表于 2025-3-22 22:59:30
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Overview of HO-1 in inflammatory pathologies,ld in the centre of the molecule by four nitrogen atoms. This molecule is of fundamental importance in many biochemical pathways including oxygen transport by hemoglobin and electron transport in the respiratory chain. Heme is also a prosthetic group for numerous enzymes, which most notably in the cCRATE 发表于 2025-3-23 07:32:22
Inducible enzymes In the pathogenesis of rheumatoid arthritis,approximately 2–3% and, on average, accounts for the loss of 88 million working days per year. Thus, chronic inflammatory diseases like RA impose a considerable financial burden on national economies. Intervention therapy tends merely to limit inflammation and may induce adverse reactions but, in ge