BULB 发表于 2025-3-21 16:41:19

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BARK 发表于 2025-3-21 20:47:28

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Biomarker 发表于 2025-3-22 02:55:59

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轻打 发表于 2025-3-22 06:36:05

Cellular Models: HD Patient-Derived Pluripotent Stem Cells,ene. Traditionally, HD cellular models consisted of either patient cells not affected by disease or rodent neurons expressing expanded polyQ repeats in HTT. As these models can be limited in their disease manifestation or proper genetic context, respectively, human HD pluripotent stem cells (PSCs) a

经典 发表于 2025-3-22 10:15:50

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实现 发表于 2025-3-22 15:38:40

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Modicum 发表于 2025-3-22 17:04:04

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regale 发表于 2025-3-22 23:05:06

,Automated Operant Assessments of Huntington’s Disease Mouse Models,the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operan

思考 发表于 2025-3-23 02:21:12

,Neurophysiological Assessment of Huntington’s Disease Model Mice, fatal neurological disorder caused by an expansion of CAG repeats in the . gene. Changes in neuronal activity often precede the behavioral manifestations of HD, therefore, understanding the electrophysiology of HD is critical for identifying potential prodromal markers and therapeutic targets. This

Fillet,Filet 发表于 2025-3-23 06:33:11

,Murine Models of Huntington’s Disease for Evaluating Therapeutics,typically present later on in life, although juvenile cases do exist. The identification of the disease-causing mutation, a CAG triplet repeat expansion in the HTT gene, in 1993 generated numerous investigations into the cellular and molecular pathways underlying the disorder. HD mouse models have p
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查看完整版本: Titlebook: Huntington’s Disease; Sophie V. Precious,Anne E. Rosser,Stephen B. Dunne Book 2018 Springer Science+Business Media, LLC, part of Springer