CHECK 发表于 2025-3-23 12:16:35
Regulation of HDL Genes: Transcriptional, Posttranscriptional, and Posttranslationalction cascades; regulation at the posttranscriptional level by microRNAs and other noncoding RNAs which bind to the coding or noncoding regions of HDL genes regulating mRNA stability and translation; as well as regulation at the posttranslational level by protein modifications, intracellular traffic隐语 发表于 2025-3-23 17:31:32
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http://reply.papertrans.cn/43/4263/426211/426211_14.pngInscrutable 发表于 2025-3-24 02:48:02
Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkersse. In addition, a low level of HDL-C has been shown to be a risk factor for other diseases not related to atherosclerosis. However, recent studies have not supported a causal effect of HDL-C in the development of atherosclerosis. Furthermore, new drugs markedly elevating HDL-C levels have been disaExpressly 发表于 2025-3-24 10:12:29
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http://reply.papertrans.cn/43/4263/426211/426211_17.png平息 发表于 2025-3-24 18:39:40
Dysfunctional HDL: From Structure-Function-Relationships to Biomarkersies. However, recent clinical trials on lipid-modifying drugs that increase plasma levels of HDL-C have not shown significant clinical benefit. Notably, in some recent clinical studies, there is no clear association of higher HDL-C levels with a reduced risk of cardiovascular events observed in patiConstant 发表于 2025-3-24 20:22:03
HDL and Atherothrombotic Vascular Diseaseeven facilitate lesion regression. These activities include promoting cellular cholesterol efflux, protecting low-density lipoproteins (LDLs) from modification, preserving endothelial function, as well as anti-inflammatory and antithrombotic effects. However, questions remain about the relative impoLATER 发表于 2025-3-25 02:28:52
HDLs, Diabetes, and Metabolic Syndromeassociated with significant morbidity and mortality, in particular with an excess of cardiovascular deaths. Type 2 diabetes mellitus and the cluster of pathologies including insulin resistance, central obesity, high blood pressure, and hypertriglyceridemia that constitute the metabolic syndrome are