COKE 发表于 2025-3-23 10:20:26
Loss of Liver Cytochrome P-450 Caused by Chemicals,hat of cytochrome P-450); this is one aspect of the more general adaptive response, usually referred to as induction of the drug-metabolizing system, which has been dealt with by . and . in Chapter 2. There are cases, however, in which a chemical causes a decrease rather than an increase in the concVEST 发表于 2025-3-23 16:58:26
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http://reply.papertrans.cn/43/4256/425576/425576_13.pngyohimbine 发表于 2025-3-23 23:03:08
The Effect of Chemicals on Hepatic Heme Biosynthesis,shown to be the major site of the metabolic disturbance contained large amounts of uro-, copro-, and proto-porphyrin. Sedormid (Fig. 1 a) has a structure closely similar to the barbiturate group of drugs (Fig. 1 b). Investigation of the relationship between structure and porphyrin inducing activity宽宏大量 发表于 2025-3-24 05:17:55
Pharmacogenetics in the Field of Heme Metabolism: Drug Sensitivity in Hereditary Hepatic Porphyria,ed by genetically determined aberrations in metabolic pathways. This far-sighted observation was neglected for many years. However, with the recognition in the 1950’s that several “idiosyncratic” drug reactions, such as primaquine-induced hemolytic anemia and suxamethonium-induced prolonged apnoea,acolyte 发表于 2025-3-24 09:33:43
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