我要沮丧
发表于 2025-3-25 04:20:48
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烧瓶
发表于 2025-3-25 10:25:32
Antiviral Drug Resistance in Herpesviruses,) and varicella-zoster virus (VZV) infections. The modest activity of ACV against human cytomegalovirus (HCMV) has prompted the development of another nucleoside analogue, ganciclovir (GCV), for the management of systemic and organ-specific HCMV diseases. Second-line agents such as the pyrophosphate
GEM
发表于 2025-3-25 13:32:11
Azole Resistance in ,: Mechanisms, Route of Resistance Selection, and Clinical Implications,rophytic mold .. However, acquired azole resistance in . is an emerging problem that compromises the clinical efficacy of azole antifungals. Several mutations in the cyp51A gene of . affect the activity of all mold-active antifungal azoles. These mutations result in the complete loss of activity of
取之不竭
发表于 2025-3-25 18:36:46
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要素
发表于 2025-3-25 20:06:08
Drug Resistance in ,,o vaccine available yet, the control of these parasites relies solely on chemotherapy. Low-cost antimony-derived compounds remain the primary antileishmanial treatment in most developing countries. Increasing drug resistance towards these molecules has forced the use of alternative therapies in high
毗邻
发表于 2025-3-26 03:47:12
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NUDGE
发表于 2025-3-26 05:03:12
HBV Therapy and the Problem of Drug Resistance,e risk of liver disease progression, including cirrhosis, hepatic failure, and hepatocellular carcinoma. Nucleos(t)ide analogue monotherapy is commonly used as first-line therapy, and most patients will require long-term antiviral therapy. As for all direct-acting antiviral agents, the emergence of
含铁
发表于 2025-3-26 09:48:41
HIV Drug Resistance in Mothers and Infants Following Use of Antiretrovirals to Prevent Mother-to-Chection in the plasma is standard of care for prevention of mother-to-child transmission of HIV (.). In many resource-limited communities, financial and infrastructure limitations preclude ART for pregnancy. Instead, abbreviated PMTCT regimens of short-term antiretrovirals (.) (mono- or dual therapy)
IOTA
发表于 2025-3-26 13:55:56
HIV Protease Inhibitor Resistance,fic HIV protease inhibitors (PIs), based on thorough understanding of the structure of HIV protease and its substrate, serves as a prime example of structure-based drug design. The introduction of first-generation PIs marked the start of combination antiretroviral therapy. However, low bioavailabili
cushion
发表于 2025-3-26 20:08:55
HIV-1 Drug Resistance in Preexposure Prophylaxis Trials,tive in multiple randomized, placebo-controlled clinical trials throughout the world. Preexposure prophylaxis trials have included over 20,000 men and women at risk for HIV infection through sexual or intravenous exposure. A consistent finding is that drug exposure is essential for PrEP efficacy. In