Decibel
发表于 2025-4-1 02:53:19
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带来
发表于 2025-4-1 08:12:56
Selection of High-Affinity Heterodimeric Antigen-Binding Fc Fragments from a Large Yeast Display Liunction as parts of bispecific IgG-like symmetrical antibodies when they replace their wild-type Fc. Their homodimeric structure typically leads to bivalent antigen binding. In particular, biological situations monovalent engagement, however, would be preferred, either for avoiding agonistic effects
BILIO
发表于 2025-4-1 11:29:02
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chandel
发表于 2025-4-1 14:27:21
Single-Cell B-Cell Sequencing to Generate Natively Paired scFab Yeast Surface Display Libraries,onoclonal antibodies (mAbs). Using scRNA-seq to determine natively paired B-cell receptor (BCR) sequences of immunized mice as a starting point for design, this method outlines a simplified workflow to express single-chain antibody fragments (scFabs) on the surface of yeast for high-throughput chara
remission
发表于 2025-4-1 18:30:28
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lactic
发表于 2025-4-2 00:59:51
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不能和解
发表于 2025-4-2 02:49:00
Accessing Transient Binding Pockets by Protein Engineering and Yeast Surface Display Screening,tion with other molecules. The inability to reach the binding pocket can impose a substantial or even insurmountable barrier for the de novo identification or optimization of small-molecule ligands. Herein, we describe a protocol for the engineering of a target protein and a yeast display FACS sorti
employor
发表于 2025-4-2 07:11:55
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