雀斑
发表于 2025-3-26 23:31:20
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OMIT
发表于 2025-3-27 01:38:15
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canonical
发表于 2025-3-27 09:16:33
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MAIZE
发表于 2025-3-27 11:16:54
B. Paula Luengo Kanacri,Gloria Jiménez-Moyaional mutagenesis has prompted reassessment of the genotoxic potential of integrating vector systems. In this chapter, various strategies are described to reduce the associated risks of retroviral genomic integration. These include deletion of strong transcriptional enhancer-promoter elements in the
ANTE
发表于 2025-3-27 16:14:09
https://doi.org/10.1057/9780230391673e and polyadenylation signal. The promoter is essential to control expression of the therapeutic gene. A tissue-specific promoter is a promoter that has activity in only certain cell types. Use of a tissue-specific promoter in the expression cassette can restrict unwanted transgene expression as wel
CRAB
发表于 2025-3-27 19:10:42
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ESPY
发表于 2025-3-28 01:55:27
https://doi.org/10.1057/9781137350312viral vectors that can be used to treat human diseases in the clinic. Ideally, regulatable cassettes should have minimal gene expression in the “OFF” state, and expression should quickly reach therapeutic levels in the “ON” state. In addition, the components of regulatable cassettes should be non-to
Lymphocyte
发表于 2025-3-28 03:36:11
chanism. SB has been shown to mediate transposition in a variety of cells and tissues, has been used for the generation of transgenic animals and has been tested as a vector for gene therapy in several animal models of human disease. Here, we describe methods that we have developed for testing SB-me
使苦恼
发表于 2025-3-28 09:57:32
correction of mutated genes directly in the chromosome. This kind of gene therapy is based on homologous recombination, which can be stimulated by the creation of a targeted DNA double-strand break (DSB) near the site of the desired recombination event. Artificial nucleases containing zinc finger D
羽毛长成
发表于 2025-3-28 12:56:12
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