agnostic
发表于 2025-3-26 23:37:06
king mice. Presently, approximately 70% of the protein-coding genes in the mouse genome have been disrupted by gene-trap insertions. Here we describe the basic methodology used to induce and characterize gene-trap mutations in ESCs.
Conflagration
发表于 2025-3-27 02:53:31
Levels of Analysis: The Inter-state Leveluse genome. The resulting mouse models are leading to a better understanding of the molecular and cellular basis of dosage alterations in human disease phenotypes, in turn opening new diagnostic and therapeutic opportunities.
平庸的人或物
发表于 2025-3-27 08:20:26
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五行打油诗
发表于 2025-3-27 12:14:25
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ESO
发表于 2025-3-27 15:11:45
Gene-Trap Vectors and Mutagenesisking mice. Presently, approximately 70% of the protein-coding genes in the mouse genome have been disrupted by gene-trap insertions. Here we describe the basic methodology used to induce and characterize gene-trap mutations in ESCs.
Aggressive
发表于 2025-3-27 21:25:38
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Agnosia
发表于 2025-3-27 22:25:28
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爱好
发表于 2025-3-28 02:52:38
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constitute
发表于 2025-3-28 09:07:20
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打算
发表于 2025-3-28 14:25:15
eeding to render potential recessive mutations homozygous, at which time phenotype screens can be performed. An alternative strategy for randomly mutagenizing the mouse genome is by chemical treatment of ES cells. This enables the use of multiple alternative chemicals with different mutational spect