枕垫
发表于 2025-3-28 15:41:10
Development of Antisense Oligonucleotide Gapmers for the Treatment of Dyslipidemia and Lipodystrophy diseases, the translation of the genetic mechanisms into a clinical setting has been quite challenging, with a minimum number of effective treatments available. The advancements in antisense therapy have revolutionized the field of neuromuscular disorders as well as lipid-mediated diseases. With th
大方不好
发表于 2025-3-28 19:00:15
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难解
发表于 2025-3-29 01:23:39
Degradation of Toxic RNA in Myotonic Dystrophy Using Gapmer Antisense Oligonucleotidesf repeat sequences in the . and . genes, respectively. The expansions are highly unstable and biased for further expansion in somatic cells and across generations. Despite the different genes involved, DM1 and DM2 share several clinical features due to having the similar underlying mechanism of repe
软弱
发表于 2025-3-29 04:23:19
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textile
发表于 2025-3-29 09:27:10
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即席
发表于 2025-3-29 14:40:13
Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modificatioing is the lack of appropriate in vitro validation systems that can predict in vivo activity and toxicity. We have devised a transfection method called CEM (Ca.-enrichment method), where the simple enrichment of calcium ion with calcium chloride in culture medium potentiates the activity of various
Patrimony
发表于 2025-3-29 19:27:27
Evaluating the Knockdown Activity of MALAT1 ENA Gapmers In Vitrotherapeutic purposes. For in vitro evaluation of the knockdown activity of gapmer ASOs, we often use lipofection or electroporation to deliver gapmer ASOs into the cells. Here, we describe a method for evaluating the knockdown activity of gapmer ASOs by a cell-free uptake mechanism, termed as gymnos
揭穿真相
发表于 2025-3-29 19:53:21
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Type-1-Diabetes
发表于 2025-3-30 00:38:00
Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expisease appears to manifest sporadically. The recent discovery of the hexanucleotide repeat expansion in the C9orf72 gene as the causative agent of ALS (C9ALS) gives rise to the opportunity to develop new therapies directed at this mutation, which is responsible for a large proportion of ALS and/or f
BUOY
发表于 2025-3-30 06:04:21
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