Talkative
发表于 2025-3-25 06:50:54
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珍奇
发表于 2025-3-25 08:21:54
1064-3745 tocols, and tips on troubleshooting and avoiding known pitfalls... Authoritative and cutting-edge, .Gapmers: Methods and Protocols. aims to provide diverse applications of gapmers along with protocols that will assist readers in moving the frontier..978-1-0716-0773-2978-1-0716-0771-8Series ISSN 1064-3745 Series E-ISSN 1940-6029
松鸡
发表于 2025-3-25 13:44:13
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不可知论
发表于 2025-3-25 17:50:10
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Innocence
发表于 2025-3-25 20:57:21
https://doi.org/10.1007/978-94-009-0223-7that have a PS backbone flanked with the modified AOs on both sides. Mipomersen (trade name Kynamro), a 2′-.-methoxyethyl (MOE) gapmer, was approved by the Food and Drug Administration (FDA) for the treatment of homozygous familial hypercholesterolemia (HoFH) in 2013. Volanesorsen, another 20-mer MO
ABHOR
发表于 2025-3-26 02:55:05
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尽忠
发表于 2025-3-26 07:08:25
Computing with the Unpredictable RNase H cleavage while having enhanced target binding affinity and nuclease resistance. This chapter will consolidate the different strategies studied thus far to develop a treatment for DM1 through the targeting of toxic repetitive RNA using gapmers.
凹处
发表于 2025-3-26 11:59:37
Geometric and Algebraic Canonical Formsothioate or phosphodiester backbone modifications. This work offers a strategy to optimize gapmer ASO pharmacokinetics by a proposed endogenous assembly process with serum albumin that can be tuned by gapmer ASO design modifications.
–FER
发表于 2025-3-26 13:32:41
Jumpei Tsujiuchi,George W. Strokef72 repeat expanded transcripts resulted in recovery from the disease-related phenotypes in patient-derived fibroblasts. Our findings highlight the therapeutic potential of C9ALS using this gapmer oligonucleotide-based approach.
doxazosin
发表于 2025-3-26 17:26:03
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