繁荣地区
发表于 2025-3-23 10:03:21
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Campaign
发表于 2025-3-23 16:55:36
,Experiment-Guided Molecular Modeling of Protein–Protein Complexes Involving GPCRs,l, while other types of data are more useful at the stage of solution filtering. The protocol was successfully applied to modeling and design of a stable construct that resulted in crystallization of the first complex between a chemokine and its receptor. Examples from this work are used to illustra
缩短
发表于 2025-3-23 20:09:21
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Critical
发表于 2025-3-23 23:58:01
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询问
发表于 2025-3-24 04:42:56
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保留
发表于 2025-3-24 09:54:39
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进取心
发表于 2025-3-24 12:41:50
https://doi.org/10.1007/978-981-97-0206-0nd .. a measure of affinity) allows the identification of agonists that demonstrate unique signaling either for different signaling pathways linked to the receptor, differences in cellular host, effects of receptor mutation, or receptor selectivity profiles. The procedure includes statistical methods to assess the significance of these effects.
PRO
发表于 2025-3-24 17:47:46
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Enliven
发表于 2025-3-24 20:43:13
21. Deutscher Soziologentag 1982ciated with exon 11. These exon 11-associated truncated variants are not readily labeled with current radioligands. Here we describe the synthesis of a radioiodinated ligand suitable for carrying out binding studies for this target.
剧毒
发表于 2025-3-25 00:33:32
Bruno S. Frey,Christoph A. Schalteggerunable to discriminate between different, yet energetically similar, poses because of their relatively simple scoring functions. Here, we describe a metadynamics-based approach to study the dynamic process of ligand binding to/unbinding from GPCRs with a higher level of accuracy and yet satisfying efficiency.