格言
发表于 2025-3-26 23:20:21
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举止粗野的人
发表于 2025-3-27 02:56:08
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创作
发表于 2025-3-27 08:27:06
New Insights into GPCR Function: Implications for HTS,ique targeted therapeutic uses, including “designer” drugs such as allosteric regulators, inverse agonists, and drugs targeting hetero-oligomeric complexes. This has been facilitated by the development of new screening technologies to identify novel drugs against both known and orphan GPCRs.
滔滔不绝地说
发表于 2025-3-27 09:26:48
An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRf structure-based drug design has been possible. Much effort has been dedicated to structural biology on GPCRs and very recently an X-ray structure of the β2-adrenergic receptor was obtained. This breakthrough will certainly increase the efforts in structural biology on GPCRs and furthermore speed up and facilitate the drug discovery process.
Prognosis
发表于 2025-3-27 16:02:02
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cipher
发表于 2025-3-27 20:33:57
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航海太平洋
发表于 2025-3-27 23:53:10
BacMam: Versatile Gene Delivery Technology for GPCR Assays,ample, coexpression of a receptor and a G protein or a reporter gene. BacMam viruses are compatible with the GPCR cell-based assay formats typically used in high-throughput screening and provide an unparalleled level of experimental flexibility that is simply not possible when using stable recombinant cell lines.
新陈代谢
发表于 2025-3-28 03:58:22
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笼子
发表于 2025-3-28 08:17:58
Resonant Waveguide Grating Biosensor for Whole-Cell GPCR Assays,disease relevant environments. We have shown that these biosensor assays enable high-throughput screening of pathway-biased ligands acting on endogenous β.-adrenergic receptor in cells. These biosensor cellular assays hold the potential to reduce attrition rates in drug discovery and development process.
泰然自若
发表于 2025-3-28 11:17:26
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