LURE
发表于 2025-3-26 23:29:59
Complex System Reliability Analysis Methods,olecular mechanisms underlying the therapeutic properties of the phytocannabinoids, the active compounds in this plant, occurred in the last years of the past century. In the late 1980s and early 1990s, seminal studies demonstrated the existence of cannabinoid receptors and other elements of the so-
MOTIF
发表于 2025-3-27 01:25:10
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membrane
发表于 2025-3-27 07:45:13
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affluent
发表于 2025-3-27 10:03:41
Application of the binomial distribution,ion of a wide variety of chemical and physical noxious stimuli, ranging from exogenous and endogenous ligands to noxious heat (>42 °C) and low pH (pH < 5.2). Due to its central role in pain and hyperalgesia, TRPV1 is considered a relevant therapeutic target for the development of analgesic and anti-
incisive
发表于 2025-3-27 17:00:37
Systems with non-exponential distributions,esity, inflammatory-related diseases, and cancer. Therefore, identifying novel drugs that are able to restore PPAR-γ activity is a current challenge, which is however slowed down by the lack of a rapid and reproducible activity assay. To date, only a few methods are able to characterize PPAR-γ activ
MOTIF
发表于 2025-3-27 20:48:30
Reliability Evaluation of Power Systemsrent selectivity for the PPAR α, γ, and δ subtypes have been introduced into the market or have reached advanced clinical trials. Binding assays are of utmost importance for the discovery and profiling of such PPAR ligands. Binding assays are often based on radioligands, in particular, tritiated mol
无可争辩
发表于 2025-3-28 00:10:41
https://doi.org/10.1007/978-1-4899-1860-4ysiologic processes, through heterodimerization with retinoid X receptor and complex formation with various cofactors. The specific cofactors recruited to PPAR-RXR complexes in response to different ligands lead to major differences in the transactivation of target genes. We developed a cofactor rec
可商量
发表于 2025-3-28 03:03:46
Rui Peng,Qingqing Zhai,Jun Yangs) of G-protein coupled receptor ligands. Here, we describe the cyclic AMP assay that is carried out with commercially available nonradioligand ready-to-use kits and CHO (Chinese Hamster Ovarian) cells stably transfected with the human cannabinoid CB. receptor.
ULCER
发表于 2025-3-28 07:36:11
Heat Generation and Dissipation,ation by (partial) agonists including the G protein pathway and the recruitment of β-arrestins. Differences in the activation level of these pathways lead to biased signaling. Here, we describe a detailed protocol to characterize the potency and efficacy of ligands to induce or inhibit β-arrestin re
预防注射
发表于 2025-3-28 12:45:47
Materials and Device Degradation,r the development of novel therapeutic drugs for treating several diseases. However, the need for strategies to circumvent the unwanted psychotropic and immunosuppressive effects associated with cannabinoid receptor agonism/antagonism has led to considerable research in the field of molecular altern