EVOKE 发表于 2025-3-21 18:44:52

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没有贫穷 发表于 2025-3-21 23:38:18

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Demulcent 发表于 2025-3-22 04:20:17

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手铐 发表于 2025-3-22 07:35:41

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nominal 发表于 2025-3-22 08:54:56

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Adrenaline 发表于 2025-3-22 16:27:36

https://doi.org/10.1007/978-3-642-92507-8luding leukemia 2023, kidney cancer, and melanoma (Siegel, CA Cancer J Clin 73(1):17–48, 2023). The development of targeted therapies, in particular, has dramatically altered the therapeutic landscape and improved outcomes for patients. Despite the seismic changes that have occurred in the field, so

Adrenaline 发表于 2025-3-22 18:05:17

dbreaking initiative had fundamentally changed the oncology dose-finding paradigm: discouraging outdated conventions since the era of cytotoxic agents (identifying the maximum tolerated dose, MTD), and embracing new practices of identifying the optimal dosage among multiple doses based on totality o

Fantasy 发表于 2025-3-22 22:08:46

Bits, Bytes, Words and Numbers,e treatments, oncology trials need to start human research at a lower dose level and then move up and down through some dose levels in a process called dose finding that helps determine a safe dose level. The toxicity of these oncology drugs is always assumed to increase with dose. However, unlike i

IOTA 发表于 2025-3-23 03:41:01

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glucagon 发表于 2025-3-23 06:27:12

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查看完整版本: Titlebook: Dose Finding and Beyond in Biopharmaceutical Development; Jingjing Ye,Ding-Geng Chen,Joseph C. Cappelleri Book 2025 The Editor(s) (if appl