Nonconformist
发表于 2025-3-27 00:16:38
Service Integration in Supported Employmentcytes. Multiple hepatocyte derived cellular carcinoma cell lines, such as HepG2, Huh7, and HepaRG cells, have been established over the years, and they display distinct characteristics regarding the expression and activity levels of drug-metabolizing enzymes and other hepatocyte-specific factors. Th
Dignant
发表于 2025-3-27 04:07:17
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oblique
发表于 2025-3-27 07:35:51
Danica Damljanović,Kalina Bontchevaon reasons given for drug attrition or withdrawal; this occurs for a multitude of reasons among which is certainly the lack of adequate models able to recapitulate hepatotoxicity in vitro. The loss of compounds in late-stage testing or after marketing is a major financial burden for the pharmaceutic
薄荷醇
发表于 2025-3-27 11:07:18
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脆弱吧
发表于 2025-3-27 13:40:45
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箴言
发表于 2025-3-27 19:33:31
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HATCH
发表于 2025-3-28 01:22:50
Adaptive Reactive Rich Internet Applicationscombines automated imaging with image analysis to assess cell health and customized parameters in a multiparametric fashion, enabling coverage over several mechanisms important for DILI. In simple two-dimensional cell models, various HCS assays typically show a sensitivity of ~50% with a high specif
Incompetent
发表于 2025-3-28 04:01:13
https://doi.org/10.1007/978-1-4939-7677-5Acute liver failure; Drug development; Regulatory processes; Preclinical and clinical studies; Hepatotox
Cumulus
发表于 2025-3-28 10:11:17
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Flavouring
发表于 2025-3-28 11:12:34
Background Agents and Local Notifications,phases of drug development. Considerable efforts are dedicated to the detection and understanding of idiosyncratic DILI, and to the prediction of intrinsic DILI. Ever more complex and biologically relevant in vitro models are emerging for compound prescreening purposes. These data are also being use