Nonflammable 发表于 2025-3-23 12:17:21
https://doi.org/10.1007/978-3-031-06493-7 neurites, axons, and dendrites are important for the formation of functional neuronal circuits. The actin cytoskeleton has major roles in the morphological development of neurons. In this chapter, we focused on the distribution and function of the actin-binding protein, drebrin, to elucidate the im红润 发表于 2025-3-23 15:17:47
https://doi.org/10.1007/978-3-031-06493-7 a fundamental unit for information processing of the brains. Previous studies have demonstrated the roles of drebrin in the formation of dendritic spines and in the recruitment of synaptic proteins to postsynaptic sites. Further, a live imaging study has revealed the unique dynamics of drebrin in d刚开始 发表于 2025-3-23 20:25:35
https://doi.org/10.1007/978-3-031-06592-7ostsynaptic sites plays a pivotal role in synaptic plasticity. In this chapter, we review the role of drebrin in the regulation of the actin cytoskeleton during synaptic plasticity, under long-term potentiation (LTP) and long-term depression (LTD). Dendritic spines have two F-actin pools, drebrin-de腐蚀 发表于 2025-3-23 22:28:49
Clinton Enoch,Christoph Krause,Jane Porathas an abundance of two abnormal structures, amyloid plaques (senile plaques) and neurofibrillary tangles. In addition, drebrin loss is another hallmark of AD brains, which is a common feature in the brain of both AD patients and AD mouse models. Strong evidence from human genetics and transgenic mouRespond 发表于 2025-3-24 04:57:43
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Book 2017including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer’s disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in vario