Narcissist
发表于 2025-3-23 10:36:46
Hydrostatik (Statik der Flüssigkeiten)NT; SLC29 gene family) nucleoside transporters, which differ in their substrate selectivity and their energy requirements. Both nucleoside transporter families have also been involved in the transmembrane transport of nucleoside-derived compounds, many of them currently used in antiviral and antitum
柱廊
发表于 2025-3-23 14:04:44
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GROSS
发表于 2025-3-23 18:09:55
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Antagonism
发表于 2025-3-23 22:56:56
Hydrostatik (Statik der Flüssigkeiten)de analogs need to be phosphorylated to attain full clinical potency; thus, knowledge of the metabolism of this class of drugs is required to improve their clinical use. The 5′-nucleotidases are a family of enzymes that catalyze the final dephosphorylation step of nucleotides in the cell and, by opp
行乞
发表于 2025-3-24 04:28:32
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Generic-Drug
发表于 2025-3-24 07:19:50
Karl-Heinrich Grote,Jörg Feldhusenoietic malignancies. The activity of ara-C depends on the conversion to its cytotoxic triphosphate derivative, ara-CTP. This process is influenced by multiple factors, including transport, phosphorylation, deamination, and levels of competing metabolites, deoxycytidine triphosphate in particular. Fu
俗艳
发表于 2025-3-24 11:15:08
Hydrostatik (Statik der Flüssigkeiten)the drug in acute leukemias is favorable relative to fludarabine or cladribine and may have prognostic value for its clinical activity. The toxicity profile of this agent is different from other nucleoside analogs in that it clearly has clinical activity when used as a single agent against adult acu
宏伟
发表于 2025-3-24 18:45:38
Beanspruchung stabförmiger Bauteiledes and nucleoside analogs are available. Among nucleoside analogs, nonnatural L-enantiomers have been particularly interesting. The most notable example is lamivudine, which has been playing an important role in the treatment of human immunodeficiency virus and hepatitis B virus infections. The rea
相容
发表于 2025-3-24 21:04:59
Wolfgang Beitz,Karl-Heinz Küttnerg DNA synthesis and inducing apoptosis following their incorporation into DNA. Troxacitabine (Troxatyl™ Shire Biochem, Inc., exclusively licensed to SGX Pharmaceuticals, Inc.) is the first nucleoside analog with anticancer activity that has an unnatural stereochemical configuration. Its broad precli
PLAYS
发表于 2025-3-24 23:51:50
Mechanische Konstruktionselemente,1995 before a prodrug of ara-G, nelarabine, entered clinical trials. Ara-G is a deoxyguanosine analog that needs to be phosphorylated inside the cell for pharmacological activity. In the first and rate-limiting phosphorylation step, ara-G is a substrate of both the mitochondrial deoxyguanosine kinas