杂役
发表于 2025-3-25 04:46:42
Peng Zhang,Xiaoyu Ge,Jochen Renzased on their ability to form and change their three-dimensional structure. Binding of divalent ions to specific binding pockets was found to be important for the global structure and function. Here, we present a protocol that allows counting the number of Mn.-binding sites and to determine their di
Fracture
发表于 2025-3-25 09:46:50
Peng Zhang,Xiaoyu Ge,Jochen Renz obtain well-diffracting single crystals and to solve the phase problem. The absence of structural information impedes the elucidation of the molecular details of biological processes. A particularly intriguing example is the RNA-cleavage catalyzed by the 10–23 deoxyribozyme (DNAzyme). This DNAzyme
idiopathic
发表于 2025-3-25 14:33:37
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弄污
发表于 2025-3-25 19:00:52
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支形吊灯
发表于 2025-3-25 21:38:58
Peng Zhang,Xiaoyu Ge,Jochen Renzlations. However, as DNA or RNA are highly charged molecules, performing such simulations is challenging as to the representation of intramolecular electrostatic interactions and those to solvent molecules and ions. This is particularly true for DNAzymes, where DNA and RNA backbones can come as clos
REP
发表于 2025-3-26 01:40:08
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mendacity
发表于 2025-3-26 06:43:40
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phytochemicals
发表于 2025-3-26 11:39:14
https://doi.org/10.1007/978-3-031-00119-2s, for example, oligonucleotides. In order to be applicable, the oligonucleotide has to be labeled site-specifically with paramagnetic tags, the so-called spin labels. Here, we provide a protocol for spin labeling of long oligonucleotides with nitroxides. In the first step, a short and commercially
metropolitan
发表于 2025-3-26 16:14:57
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Conspiracy
发表于 2025-3-26 17:24:54
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