纤细
发表于 2025-3-26 23:26:02
Yongbin Zhang,Xiuli Fu,Li Wei,Yanying ZhengDNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.
conceal
发表于 2025-3-27 01:11:33
Tim Schlippe,Eric C. K. Cheng,Tianchong WangCondensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.
galley
发表于 2025-3-27 06:47:41
On-DNA Reductive Amination and Alkylation,On-DNA reductive amination (on-DNA aldehyde with amine building blocks) and alkylation (on-DNA amine with aldehyde building blocks) are robust ways to form C-N bond. The large sets of commercially available aldehyde and amine building blocks make reductive amination and alkylation widely used in DEL synthesis.
玩忽职守
发表于 2025-3-27 10:12:48
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obsession
发表于 2025-3-27 14:00:20
On-DNA Suzuki-Miyaura Cross-Coupling,Suzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh.). as coupling catalyst.
安抚
发表于 2025-3-27 20:05:57
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preservative
发表于 2025-3-28 00:00:06
Ruthenium-Promoted On-DNA C-H Activation Reaction,DNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.
BADGE
发表于 2025-3-28 03:49:31
Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of IsoquinoloneCondensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.
PHONE
发表于 2025-3-28 06:53:52
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波动
发表于 2025-3-28 14:26:05
978-1-0716-2547-7Springer Science+Business Media, LLC, part of Springer Nature 2022