Gesture
发表于 2025-3-25 06:46:53
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Indict
发表于 2025-3-25 10:46:40
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FELON
发表于 2025-3-25 12:42:50
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exhibit
发表于 2025-3-25 16:38:40
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不开心
发表于 2025-3-25 20:19:45
Ala’a Gharaibeh,Normalini Md Kassimures compared to other small molecule screening technologies, such as the use of DNA identification tags and use of target protein immobilization in the standard library screening process. Therefore, it is of great importance to ensure the target protein is properly designed for DEL selections, that
epicondylitis
发表于 2025-3-26 03:13:29
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护航舰
发表于 2025-3-26 06:42:38
Artificial Intelligence in EducationOn-DNA reductive amination (on-DNA aldehyde with amine building blocks) and alkylation (on-DNA amine with aldehyde building blocks) are robust ways to form C-N bond. The large sets of commercially available aldehyde and amine building blocks make reductive amination and alkylation widely used in DEL synthesis.
绅士
发表于 2025-3-26 09:04:01
Vaclav Bayer,Martin Hlosta,Miriam FernandezCopper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug discovery. Described herein is a protocol for the CuSO.-catalyzed cycloaddition between alkynes and DNA-appended azides.
Lignans
发表于 2025-3-26 14:21:04
Tianchong Wang,Eric C. K. ChengSuzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chemistry. Here we describe the efficient cross-coupling with on-DNA halide substrates using Pd(PPh.). as coupling catalyst.
Arteriography
发表于 2025-3-26 16:48:23
Xinqiang Meng,Le Qi,Mengyang LiuOptimal conditions of palladium-catalyzed on-DNA Heck reactions were developed between DNA-conjugated acryl amide/styrene/aryl iodide and broad substrate scopes (aromatic borates/halides/styrene), which can introduce the diversity of building blocks to DNA-encoded libraries.