Neutropenia
发表于 2025-3-30 11:23:51
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agitate
发表于 2025-3-30 15:39:02
Armand Graaff,Danie Smit,Sunet Eybersing a 3′-DNA covalent intermediate and a 5′-terminus (5′-OH). Strand ligation occurs during a second transesterification event when the 5′-OH displaces the enzyme (. .). A change in DNA linking number results when strand unwinding occurs between these cleavage and ligation reactions.
Irksome
发表于 2025-3-30 19:21:46
ICE Bioassay,the cleavage site. This ability of topoisomerases to catalyze concerted breaking and rejoining of DNA strands makes them biologically important enzymes that are involved in crucial cellular processes (.–.).
惊惶
发表于 2025-3-30 23:41:35
Quinolone Interactions with DNA and DNA Gyrase,ocess of drug design by furthering our understanding of the established structure-activity relationship of that class of compounds. The method has been best exemplified by the investigations of mode of action of quinolone antibacterials that target the bacteria-specific type II DNA topoisomerase, DNA gyrase (reviewed in . .–.).
cathartic
发表于 2025-3-31 04:55:36
Bactericidal Assays for Fluoroquinolones,ented in many other organisms, indicating that DNA gyrase is a universal target for these drugs. This relationship has been somewhat complicated recently by the observation that in ., mutations in another type II enzyme, topoisomerase IV, also confer resistance to fluoroquinolones (.).
白杨鱼
发表于 2025-3-31 07:05:37
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沟通
发表于 2025-3-31 10:30:06
,Synthesis and Use of DNA Containing a 5′-Bridging Phosphorothioate as a Suicide Substrate for Type ing a 3′-DNA covalent intermediate and a 5′-terminus (5′-OH). Strand ligation occurs during a second transesterification event when the 5′-OH displaces the enzyme (. .). A change in DNA linking number results when strand unwinding occurs between these cleavage and ligation reactions.
腼腆
发表于 2025-3-31 14:48:46
Fawwaz Mohammed,Lisa F. Seymourthe cleavage site. This ability of topoisomerases to catalyze concerted breaking and rejoining of DNA strands makes them biologically important enzymes that are involved in crucial cellular processes (.–.).
严厉批评
发表于 2025-3-31 19:31:59
https://doi.org/10.1007/978-3-030-95070-5ocess of drug design by furthering our understanding of the established structure-activity relationship of that class of compounds. The method has been best exemplified by the investigations of mode of action of quinolone antibacterials that target the bacteria-specific type II DNA topoisomerase, DNA gyrase (reviewed in . .–.).
Occlusion
发表于 2025-3-31 22:07:02
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