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The Role of Active Demethylation in Cancer and Its Therapeutic Potential,s-associated genes. Thus, anticancer therapy directed at DNA methyltransferase might have the untoward effect of promoting metastasis. Inhibition of demethylase activity on the other hand could potentially inhibit metastasis. It is therefore important to identify and characterize the enzymes responsible for global hypomethylation in cancer.1FAWN 发表于 2025-3-31 12:17:52
Purine Analogues and Their Role in Methylation and Cancer Chemotherapy,tween purine and pyrimidine nucleotide metabolism, cell proliferation and tumor cell differentiation, inhibition of key enzymes in nucleotide metabolism and DNA synthesis can be used as a chemotherapeutic approach to treating cancer.