Coeval 发表于 2025-3-25 03:30:08
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https://doi.org/10.1007/978-3-642-24996-9methylation of CpG islands of tumor suppressor genes associated with their transcriptional silencing. The target genes are distributed in all cellular pathways (apoptosis, DNA repair, cell cycle, cell adherence, etc.). They are “classical” tumor suppressor genes with associated familial cancers (BRCobsession 发表于 2025-3-25 18:07:40
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https://doi.org/10.1007/978-3-642-24996-9er than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance of methylation-free regions of chromatin. In fact, several lines of in vitro and in vivo evidence have shown that poly(ADP-ribosyl)ation is involved in the control of DNA methylation pattern, prote间接 发表于 2025-3-26 16:02:26
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https://doi.org/10.1007/978-3-642-24996-9cleosides and their corresponding nucleobases are the fundamental building blocks of many biological systems and as a result, have been extensively investigated due to their inherent structural resemblance to the naturally occurring nucleosides and nucleobases. Due to the intertwined relationship be